Download e-book for iPad: Apoptosis : modern insights into disease from molecules to by Victor R. Preedy

By Victor R. Preedy

ISBN-10: 1578085837

ISBN-13: 9781578085835

Targeting the foremost energetic components within the mechanism and alertness of apoptosis and its healing implications, Apoptosis: glossy Insights into disorder from Molecules to Man covers apoptosis from A to Z. accomplished in scope, it explores quite a lot of subject matters together with a variety of cancers, bronchial asthma, and a number of sclerosis in addition to alcohol triggered liver affliction, power again soreness, and cardiovascular well-being. With forty chapters written by way of hugely revered experts, this unmarried resource reference presents researchers and scientists with the basis they need.

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Sample text

6). Even more pronounced was the effect that the two polyphenols had on the expression of the anti-apoptotic Bcl-2 protein, which was significantly over-expressed in stressed cells treated with the two polyphenols. It is worth noting that oxLDL immediately determined the over-expression of p53 protein, which remained at a high level throughout the experimental time (48 hr as from oxLDL exposure), while p66Shc over-expression was found only 6 hr after the treatment and then rapidly decreased. The temporary intracellular over-expression of p66Shc could be the key signal in determining cell fate, since it increased ROS production, and can be an important regulator of the apoptotic response to oxidative stress.

2009. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ. 16: 3-11. J. 1991. Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis. Nature 353: 858-861. I. M. K. P. H. A. J. Lenardo. 1995. Amelioration of autoimmune reactions by antigen-induced apoptosis of T cells. Adv. Exp. Med. Biol. 383: 157-166. E. S. L. L. C. Tangye. 2005. Molecular and cellular pathogenesis of X-linked lymphoproliferative disease. Immunol. Rev. 203: 180-199.

The death of a cell, via caspase activation. Other chapters of this book should be consulted for a comprehensive view of apoptotic pathways. Besides caspases, several other proteins are specifically involved in the control of the cell death programme, or in general of cell fate (death or survival). Among these, the p53 tumour-suppressor protein is involved in both apoptotic pathways. The activation/ stabilization of p53—determined by kinase phosphorylation activities in response to external or internal stress signals—is responsible for cell cycle arrest and proapoptotic gene transcription as well as for transcription-independent activities.

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Apoptosis : modern insights into disease from molecules to man by Victor R. Preedy


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